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1

A staining procedure for micronucleus test using new methylene blue and acridine orange: specimens that are supravitally stained with possible long-term storage

Tadakazu Sugihara, Shigeki Sawada, Atsushi Hakura, Yuji Hori, Kanako Uchida, Fumio Sagami

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2000

Langue:

english

Fichier:

PDF, 146 KB

english, 2000

2

Effect of Electro-acupuncture Stimulation on the Serum Cortisol Level in Dogs

Kitazawa, Kaoru, Ito, Yasutaka, Sagami, Fumio

Journal:

Zen Nihon Shinkyu Gakkai zasshi (Journal of the Japan Society of Acupuncture and Moxibustion)

Année:

1982

Fichier:

PDF, 448 KB

1982

3

Quinoline-induced chromosome aberrations and sister chromatid exchanges in rat liver

Shoji Asakura, Shigeki Sawada, Tadakazu Sugihara, Hirohiko Daimon, Fumio Sagami

Journal:

Environmental and Molecular Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 80 KB

english, 1997

4

Analysis of cytogenetic effects and DNA adduct formation induced by safrole in Chinese hamster lung cells

Hirohiko Daimon, Shigeki Sawada, Shoji Asakura, Fumio Sagami

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 86 KB

english, 1997

5

Inhibition of sulfotransferase affecting in vivo genotoxicity and DNA adducts induced by safrole in rat liver

Hirohiko Daimon, Shigeki Sawada, Shoji Asakura, Fumio Sagami

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 85 KB

english, 1997

6

Multiple organ mutation in the lacZ transgenic mouse (Muta™ Mouse) 6 months after oral treatment (5 days) with benzo[a]pyrene

Atsushi Hakura, Yoshie Tsutsui, Jiro Sonoda, Takashi Mikami, Kazuo Tsukidate, Fumio Sagami, William D Kerns

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1999

Langue:

english

Fichier:

PDF, 312 KB

english, 1999

7

Comparison of the mutational spectra of the lacZ transgene in four organs of the Muta™Mouse treated with benzo[a]pyrene: target organ specificity

Atsushi Hakura, Yoshie Tsutsui, Jiro Sonoda, Kazuo Tsukidate, Takashi Mikami, Fumio Sagami

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2000

Langue:

english

Fichier:

PDF, 91 KB

english, 2000

8

Mutagenicity of dihydroxybenzenes and dihydroxynaphthalenes for Ames Salmonella tester strains

Atsushi Hakura, Yoshie Tsutsui, Hisatoshi Mochida, Yoshiki Sugihara, Takashi Mikami, Fumio Sagami

Journal:

Mutation Research/Genetic Toxicology

Année:

1996

Langue:

english

Fichier:

PDF, 496 KB

english, 1996

9

Gangliosides in the blood plasma: levels of ganglio-series gangliosides in the plasma after administration of brain gangliosides

Yasuo Suzuki, Yoshio Hirabayashi, Fumio Sagami, Makoto Matsumoto

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1988

Langue:

english

Fichier:

PDF, 443 KB

english, 1988

10

Dog liver glutathione s-transferase and its strong immunoreactivity with rat transferase-p(7-7)

Igarashi Takashi, Nanba Eri, Sagami Fumio, Tsukidate Kazuo, Fukuda Taneo, Horie Toru, Satoh Tetsuo, Kitagawa Hario

Journal:

Biochemical Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 551 KB

english, 1988

11

Protection from drug-induced hepatocellular changes by pretreatment with conjugating enzyme inhibitors in rats

Gen Sato, Toyohiko Aoki, Satoru Hosokawa, Fumio Sagami, Kazuo Tsukidate

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 338 KB

english, 2001

12

Use of human liver S9 in the Ames test: assay of three procarcinogens using human S9 derived from multiple donors

Atsushi Hakura, Satoshi Suzuki, Shigeki Sawada, Tadakazu Sugihara, Yuji Hori, Kanako Uchida, William D Kerns, Fumio Sagami, Satoru Motooka, Tetsuo Satoh

Journal:

Regulatory Toxicology and Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 225 KB

english, 2003

13

The predictivity of preliminary embryo-fetal developmental toxicity studies: An ICH-M3 survey in Japan

Noriko Okahashi, Takashi Ikeda, Shuichi Kai, Shinichi Komatsu, Hajime Matsui, Yasuhiro Yamashita, Keiji Yamamoto, Fumio Sagami

Journal:

Toxicology Letters

Année:

2008

Langue:

english

Fichier:

PDF, 88 KB

english, 2008

14

Hepatic drug metabolizing enzymes induced by clofibrate in rasH2 mice

Naruo Katsutani, Tohru Sekido, Toyohiko Aoki, Fumio Sagami

Journal:

Toxicology Letters

Année:

2000

Langue:

english

Fichier:

PDF, 212 KB

english, 2000

15

A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea

Shoji Asakura, Hirohiko Daimon, Shigeki Sawada, Fumio Sagami

Journal:

Toxicology Letters

Année:

1998

Langue:

english

Fichier:

PDF, 138 KB

english, 1998

16

Third-party accreditation (external evaluation) for self-management of animal experiments.

Journal:

Folia Pharmacologica Japonica

Année:

2010

Fichier:

PDF, 804 KB

2010

17

Chronic Toxicity Test of Taselin in Rats

SUGIYAMA, Kazutake, SAGAMI, Fumio, CHIBA, Tanetaka

Journal:

The Japanese Journal of Veterinary Science

Année:

1974

Fichier:

PDF, 1.67 MB

1974

18

MUTAGENICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (1) : REVERSE MUTATION ASSAYS IN S.TYPHIMURIUM AND E.COLI TESTER STRAINS

HAKURA, Atsushi, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, FASSIO, Franca

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 537 KB

1999

19

REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (3) : STUDY OF EMBRYO-FETAL TOXICITY IN RABBITS BY INTRAVENOUS ADMINISTRATION

OKUDA, Yasuyuki, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, MASTERS, Robert E.

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 846 KB

1999

20

Toxicological response of rats to a novel monoamine oxidase type-A inhibitor, (5R)3-(2-((1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl)-5-methoxymethyl-2-oxazolidinone(E2011), orally administered for 13 weeks.

SATO, Gen, CHIMOTO, Tadashi, AOKI, Toyohiko, HOSOKAWA, Satoru, SUMIGAMA, Shuji, TSUKIDATE, Kazuo, SAGAMI, Fumio

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 2.99 MB

1999

21

MUTAGENICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (3) : MICRONUCLEUS TEST IN RAT BONE MARROW CELLS

TORITSUKA, Naoki, DAIMON, Hirohiko, SAWADA, Shigeki, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, FASSIO, Franca

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 482 KB

1999

22

MUTAGENICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (2) : CHROMOSOME ABERRATION TEST WITH HUMAN LYMPHOCYTES IN CULTURE

TORITSUKA, Naoki, DAIMON, Hirohiko, SAWADA, Shigeki, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, ADAMS, Kevin

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 695 KB

1999

23

COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 17)TESTICULAR TOXICITY OF E7010, A SULFONAMIDE TUBULIN POLYMERIZATION INHIBITOR

HAYAKAWA, Kazuhiro, TASHIRO, Toshifumi, SATO, Kunio, KATSURAYAMA, Tomiharu, IMAI, Toshio, HOSOKAWA, Satoru, SAGAMI, Fumio

Journal:

The Journal of Toxicological Sciences

Année:

2000

Fichier:

PDF, 1.85 MB

2000

24

REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (1) : FERTILITY STUDY IN MALE RATS BY INTRAVENOUS ADMINISTRATION

OKADA, Fumihiro, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, BAGULEY, Jane K.

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 843 KB

1999

25

CURRENT OPINION: SAFETY EVALUATION OF DRUG METABOLITES IN DEVELOPMENT OF PHARMACEUTICALS

NAITO, Shinsaku, FURUTA, Shigeru, YOSHIDA, Takemi, KITADA, Mitsukazu, FUEKI, Osamu, UNNO, Takashi, OHNO, Yasuo, ONODERA, Hiroshi, KAWAMURA, Nobuyuki, KUROKAWA, Misao, SAGAMI, Fumio, SHINODA, Kazutoshi

Journal:

The Journal of Toxicological Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 151 KB

english, 2007

26

STUDIES ON EXPERIMENTAL IODINE ALLERGY: 3. LOW MOLECULAR WEIGHT ELICITOGENIC ANTIGENS OF IODINE ALLERGY

SUGIHARA, Yoshiki, SHIONOYA, Hiroshi, OKANO, Kazuo, SAGAMI, Fumio, MIKAMI, Takashi, KATAYAMA, Kouichi

Journal:

The Journal of Toxicological Sciences

Année:

2004

Langue:

english

Fichier:

PDF, 150 KB

english, 2004

27

GENERAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (2) : SINGLE DOSE INTRAVENOUS TOXICITY STUDY IN DOGS

SEKIDO, Tohru, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, MASTERS, Robert E.

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 928 KB

1999

28

Effects of dl-.ALPHA.-tocopheryl nicotinate on coronary circulation and development of coronary collateral vessels.

YASUE, TAKAO, KATO, TOSHIHIKO, TESHIGAWARA, SEIJI, KOBAYASHI, HIROSHI, SHOJI, YOSHITAMI, HAYASE, SHOJI, OJIMA, AKITSUGU, SUGIYAMA, KAZUTAKE, SAGAMI, FUMIO

Journal:

Japanese Circulation Journal

Année:

1977

Fichier:

PDF, 1.23 MB

1977

29

What is ICH?

Journal:

Folia Pharmacologica Japonica

Année:

2007

Fichier:

PDF, 328 KB

2007

30

GENERAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (1) : SINGLE DOSE INTRAVENOUS AND INTRACISTERNAL TOXICITY STUDY IN RATS

CHIMOTO, Tadashi, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 637 KB

1999

31

Toxicokinetics: Its significance and practical problems.

KATO, Ryuichi, CASE, David E., HAKUSUI, Hideo, NODA, Kosei, SAGAMI, Fumio, HORII, Ikuo, MAYAHARA, Hiroshi, CAYEN, Mitchell N., MARRIOTT, Thomas B., IGARASHI, Toshiji

Journal:

The Journal of Toxicological Sciences

Année:

1993

Fichier:

PDF, 2.71 MB

1993

32

Collaborative work on evaluation of ovarian toxicity by repeated-dose and fertility studies in female rats

Sanbuissho, Atsushi, Yoshida, Midori, Hisada, Shigeru, Sagami, Fumio, Kudo, Satoshi, Kumazawa, Toshihiko, Ube, Masayuki, Komatsu, Shinichi, Ohno, Yasuo

Journal:

The Journal of Toxicological Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 145 KB

english, 2009

33

GENERAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (3) : 4-WEEK REPEATED DOSE INTRAVENOUS TOXICITY STUDY FOLLOWED BY 4-WEEK RECOVERY PERIOD IN RATS

AOKI, Toyohiko, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, MASTERS, Robert E.

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 1.53 MB

1999

34

STUDIES ON EXPERIMENTAL IODINE ALLERGY: 1. ANTIGEN RECOGNITION OF GUINEA PIG ANTI-IODINE ANTIBODY

SHIONOYA, Hiroshi, SUGIHARA, Yoshiki, SAGAMI, Fumio, MIKAMI, Takashi, KATAYAMA, Kouichi

Journal:

The Journal of Toxicological Sciences

Année:

2004

Langue:

english

Fichier:

PDF, 193 KB

english, 2004

35

Auto-induction of E5110 metabolism, a novel non-steroidal anti-inflammatory drug, during toxicokinetic studies in beagle dogs.

NAKATA, Hiroshi, SAGAMI, Fumio, HORIE, Toru

Journal:

The Journal of Toxicological Sciences

Année:

2000

Fichier:

PDF, 1.00 MB

2000

36

GENERAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (4) : 4-WEEK REPEATED DOSE INTRAVENOUS TOXICITY STUDY FOLLOWED BY 4-WEEK RECOVERY PERIOD IN DOGS

KATSUTANI, Naruo, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, MANDELLA, Rosemary C.

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 1.57 MB

1999

37

MUSCULAR IRRITATION STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) IN RABBITS

MIKAMI, Takashi, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, YAMADA, Yasushi, KIMURA, Hitoshi, GOTO, Katsuyuki

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 2.15 MB

1999

38

i POINTS TO CONSIDERi REGARDING SAFETY ASSESSMENT OF BIOTECHNOLOGY-DERIVED PHARMACEUTICALS IN NON-CLINICAL STUDIES (ENGLISH TRANSLATION

NAKAZAWA, Takahiro, KAI, Shuichi, KAWAI, Mutsufumi, MAKI, Eiji, SAGAMI, Fumio, ONODERA, Hiroshi, KITAJIMA, Satoshi, INOUE, Tohru

Journal:

The Journal of Toxicological Sciences

Année:

2004

Langue:

english

Fichier:

PDF, 70 KB

english, 2004

39

The predictivity of preliminary embryo-fetal development (EFD) studies: results of a retrospective survey in Japanese pharmaceutical companies

Okahashi, Noriko, Ikeda, Takashi, Kai, Shuichi, Komatsu, Shinichi, Matsui, Hajime, Yamashita, Yasuhiro, Yamamoto, Keiji, Sagami, Fumio

Journal:

The Journal of Toxicological Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 163 KB

english, 2010

40

REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (2) : COMBINED STUDY OF EFFECTS ON FERTILITY AND EMBRYO-FETAL TOXICITY IN FEMALE RATS BY INTRAVENOUS ADMINISTRATION

KAWAGUCHI, Takashi, SAGAMI, Fumio, TIRONE, Piero, MORISETTI, Alberto, BUSSI, Simona, BAGULEY, Jane K.

Journal:

The Journal of Toxicological Sciences

Année:

1999

Fichier:

PDF, 784 KB

1999

41

Points to consider on the non-clinical safety evaluation of anticancer drugs

Nakae, Dai, Onodera, Horoshi, Fueki, Osamu, Urano, Tsutomu, Komiyama, Noriyuki, Sagami, Fumio, Kai, Shuichi, Nishimura, Chihiro, Inoue, Tohru

Journal:

The Journal of Toxicological Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 84 KB

english, 2008

42

Safety assessment of biopharmaceuticals: Japanese perspective on ICH S6 guideline maintenance

Nakazawa, Takahiro, Kurokawa, Misao, Kimura, Kazuya, Wakata, Akihiro, Hisada, Shigeru, Inoue, Tadashi, Sagami, Fumio, Heidel, Shawn M., Kawakami, Koji, Shinoda, Kazutoshi, Onodera, Hiroshi, Kumagai, Y

Journal:

The Journal of Toxicological Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 99 KB

english, 2008

43

STUDIES ON EXPERIMENTAL IODINE ALLERGY: 2. IODINATED PROTEIN ANTIGENS AND THEIR GENERATION FROM INORGANIC AND ORGANIC IODINE-CONTAINING CHEMICALS

SHIONOYA, Hiroshi, SUGIHARA, Yoshiki, SAGAMI, Fumio, MIKAMI, Takashi, KATAYAMA, Kouichi

Journal:

The Journal of Toxicological Sciences

Année:

2004

Langue:

english

Fichier:

PDF, 106 KB

english, 2004

44

Pharmacokinetic Study of a Cepharosporin Derivative in Infant and Adult Dogs.

NAKATA, Hiroshi, ETOH, Hironori, CHIKU, Shigeru, MORIYAMA, Megumi, WATANABE, Naoaki, OKUDA, Yasuyuki, SAGAMI, Fumio, YUZURIHA, Teruaki

Journal:

Drug Metabolism and Pharmacokinetics

Année:

1999

Fichier:

PDF, 4.26 MB

1999